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Elevations of any of the three isoenzymes will increase the total creatine kinase. Laboratory tests in which there is an elevated total creatine kinase will prompt the physician to order a CK MB if symptoms of a heart attack exist.The CK MB test determines the portion of total creatine kinase that is related to the heart muscle. In addition to total creatine kinase and CK MB testing, Troponin levels are measured.

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